Gatti, G. and Perucca, E. Plasma concentrations of free and conjugated silybin after oral administration of a silybin-phosphatidylcholine complex (silipid) in healthy volunteers. Int.J Clin Pharmacol.Ther. 1994;32(11):614-617. See the summary. Milk thistle is most commonly taken for liver disease, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage from poisoning from amanita phalloides (hat of death) mushrooms, jaundice, chronic inflammatory liver disease, cirrhosis, and chronic hepatitis. If you prefer to find it near you, click the Find Flordis button above and follow the instructions, you can find a list of nearby places that carry Legalon or know how to order it. Even if your local pharmacy or health food store isn`t on the list, most can order it for customers upon request. For treatment, take 1 capsule three times a day. For maintenance: Take 1 capsule twice daily.
You should swallow the Legalon capsules whole with a glass of water. Some people take milk thistle orally for diabetes, kidney damage caused by diabetes, hangover, spleen disease, prostate cancer, inflammation of the lungs and chest, malaria, depression, uterine discomfort, increased maternal milk flow, allergy symptoms, incipient menstrual flow, obsessive-compulsive disorder (OCD), Alzheimer`s disease, Parkinson`s disease, multiple sclerosis, high cholesterol and menopausal symptoms. Batakov, E. A. Effect of Silybum marianum oil and legalon on lipid peroxidation and hepatic antioxidant systems in rats poisoned with carbon tetrachloride. Eksp.Klin Farmakol. 2001;64(4):53-55. See the summary. Milk thistle gets its name from the milky juice that comes out of the leaves when they are broken.
The leaves also have unique white markings, which, according to legend, were the milk of the Virgin Mary. The aerial parts and seeds are used to make medicines. Seeds are used more frequently. Legalon can be taken on an empty stomach; As this can result in the absorption of the active ingredient into the body faster. However, Legalon may also be taken with or after meals to prevent gastrointestinal discomfort, or as directed by your doctor. Milk thistle is also taken orally for loss of appetite, heartburn (dyspepsia), gallbladder disorders, enlarged prostate (benign prostatic hyperplasia), a blood disorder called beta-thalassemia, and infertility. Some medications are modified and broken down by the liver. Milk thistle can decrease how quickly the liver breaks down certain medications. Taking milk thistle with certain medications that are broken down by the liver can increase the effects and side effects of certain medications. Before taking milk thistle, talk to your doctor if you are taking medications that are impaired by the liver.
Milk thistle extract is likely safe when taken orally for most adults. Milk thistle sometimes causes a laxative effect. Other less common side effects include nausea, diarrhea, indigestion, intestinal gas, bloating, bloating, or pain and loss of appetite. Side effects seen with Legalon include: abdominal pain, flatulence, gas, diarrhea, indigestion, itching, loss of appetite, nausea, rash or severe allergic reactions. It is recommended to take Legalon after meals if you notice gastrointestinal effects. Legalon takes care to use the same specific milk thistle extract, known as MZ 80, which has been produced in a patented manufacturing process and studied in clinical trials to support healthy liver function.1-8 It doesn`t matter if you take Legalon before or after eating. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of the inhibition of human cytochrome P450 3A4 by selected plant extracts and commercial tinctures. Phytomedicine 2000;7:273-82. Venkataramanan R, Ramachandran V, Komoroski BJ, et al. Milk thistle, an herbal dietary supplements lowers the activity of CYP3A4 and uridine diphosphoglucurosyltransferase in human hepatocyte cultures.
Drug Metab Dispos 2000;28:1270-3. Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M. A systematic review of potential plant sources of future effective drugs for oxidant-related diseases. Inflamm.Allergy drug targets. 2009;8( 1):2-10. See the summary. The health benefit of 100 mg of silybin (silymarin compound) is equivalent to taking 1000 mg of milk thistle.13 Li, J, Lin, W.F., Pan, Y.Y., and Zhu, X.Y. Protective effect of silybin on liver damage induced by anti-TB drugs. Zhonghua Gan Zang.Bing.Za Zhi. 2010;18(5):385-386. See the summary.
Zima, T., Kamenikova, L., Janebova, M., Bukhar, E., Crkovska, J., and Tesar, V. The effect of silibin on the experimental nephrotoxicity of cyclosporine. I would like to ask the Commissioner if he is ready 1998;20(3):471-479. Bokemeyer, C., Fels, L. M., Dunn, T., Voigt, W., Gaedeke, J., Schmoll, H. J., Stolte, H., and Lentzen, H. Silibin protects against cisplatin-induced nephrotoxicity without affecting the antitumor activity of cisplatin or ifosfamide. Br J Cancer 1996;74(12):2036-2041.
Schroder, F. H., Roobol, M. J., Boeve, E. R., de Mutsert, R., Zuijdgeest-van Leeuwen, S. D., Kersten, I., Wildhagen, M. F. and van Helvoort, A. Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and increasing PSA: efficacy of a dietary supplement. Eur Urol 2005;48(6):922-930. Sayyah, M., Boostani, H., Pakseresht, S. and Malayeri, A.
Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of obsessive-compulsive disorder. Prog.Neuropsychopharmacol.Biol.Psychiatry 3-17-2010;34(2):362-365. By supporting healthy liver function and reducing the formation of free radicals and damage to body cells.1-4 Marena C and Lampertico M. Preliminary clinical development of silipid: a novel silybin complex in toxic liver diseases. Planta Med 1991;57(2):A124-A125. Presence of metabolic syndrome, defined as the presence of at least 3 out of 5 of the following: Deng JW, Shon JH, Shin HJ, et al. Effect of silymarin supplementation on the pharmacokinetics of rosuvastastatin.
Pharm Res 2008;25:1807–14. Magdalan, J., Piotrowska, A., Gomulkiewicz, A., Sozanski, T., Szelag, A. and Dziegiel, P. Influence of common used clinical antidotes on antioxidant systems in human hepatocyte cultures intoxicated with alpha-amanitin. Hum.Exp.Toxicol. 2011;30(1):38-43. Kim DH, Jin YH, Park JB, Kobashi K. Silymarin and its components are beta-glucuronidase inhibitors. Biol Pharm Bull 1994;17:443-5. Milk thistle seeds can protect liver cells from toxic chemicals and drugs. It also appears to have antioxidant and anti-inflammatory effects. Some diabetes medications include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.
Jiao Z, Shi XJ, Li ZD, et al. Population pharmacokinetics of sirolimus in de novo Chinese adult kidney transplant patients. Br.J.Clin.Pharmacol. 2009;68(1):47-60. Ramellini, G. and Meldolesi, J. Liver protection by silymarin: in vitro effect on dissociated rat hepatocytes. Drug research. 1976;26(1):69-73. See the summary.
Mira ML, Azevedo MS and Manso C. Neutralization of hydroxyl radicals by silibin, sorbinil and bendazac. Free Radical Res Commun 1987;4(125):129. Barzaghi, N., Crema, F., Gatti, G., Pifferi, G. and Perucca, E. Pharmacokinetic studies of IdB 1016, a silybin-phosphatidylcholine complex, in healthy people. Eur J drug Metab Pharmacokinet. 1990;15(4):333-338. See the summary. Bean, P. The Use of Alternative Medicine in the Treatment of Hepatitis C.
Am.Clin.Lab 2002;21(4):19-21. Legalon supports liver health to relieve fatigue, weakness and fatigue, support anti-inflammatory processes, reduce abdominal fullness and relieve nausea. Some medications that are modified by the liver are imipramine (Tofranil) and amitriptyline (Elavil); antipsychotics such as haloperidol (Haldol), risperidone (Risperdal) and chlorpromazine (Thorazine) beta-blockers such as propranolol (Inderal), metoprolol (Lopressor, Toprol XL) and carvedilol (Coreg); Tamoxifen (Nolvadex); and others. Zhang, J., Luan, Q., Liu, Y., Lee, D. Y. and Wang, Z. A comparison of diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells. Nat.Prod.Commun. 2011;6(11):1653-1656. Eurich, D., Bahra, M., Berg, T., Boas-Knoop, S., Biermer, M., Neuhaus, R., Neuhaus, P., und Neumann, U. Behandlung der Hepatitis-C-Virus-Reinfektion nach Lebertransplantation mit Silibinin bei Nonrespondern auf pegylierte Interferon-basierte Therapie. Exp.Clin.Transplant.
2011;9(1):1-6. Zusammenfassung anzeigen. Sonnenbichler, J., Goldberg, M., Hane, L., Madubunyi, I., Vogl, S., and Zetl, I. Stimulating effect of silibin on DNA synthesis in partially hepatectomized rat berbs: non-response in hepatoma and other malignant cell lines.